Abstract

Posterior reversible encephalopathy syndrome (PRES) is a novel clinic-radiological entity characterized by headache, visual disturbances, encephalopathy and seizures. Radiological features typically include bilateral symmetrical edema of posterior cerebral region especially of parieto-occipital lobe. Various conditions have been associated with PRES but toxemia of pregnancy, organ transplantation, immunosuppressive treatment, and hypertension are most commonly described. The pathophysiology of PRES is still debatable. Basically, it represents vasogenic edema resulting from the breakdown of cerebral autoregulation which if not managed promptly may lead to cytotoxic edema. Treatment of severe hypertension, seizure control, withdrawal of the causative agent and antiedema drugs are the hallmark of specific therapy in PRES. Delay in diagnosis and treatment may lead to permanent neurological impairment. Therefore, awareness of PRES is important for both obstetrician and radiologist. This article reports three cases of PRES which illustrate clinical features, diagnosis and management with the aim to draw attention of clinicians and radiologist to the existence of this clinic-radiologic entity associated with preeclampsia-eclampsia.