Abstract

Background: Luteinizing hormone (LH) surge is essential in the final stages of follicular maturation for triggering a follicle rupture, thus expelling the oocyte from the follicle and leading to its capture by the fallopian tube. In assisted conception as it is known that urinary (u) hCG has been used for several years to mimic the endogenous LH surge because there are considerable structural similarities between hCG and human (h) LH.Aim: To compare the efficacy of urinary versus recombinant hCG in final follicular maturation in COS IUI cycle.Material and methods: Prospective controlled clinical study conducted at private medical college in Dehradun during a period of 1 year and 9 months in the reproductive medicine and IVF Unit. A total of 185 infertile women were including in the study after fulfilling the inclusion criteria. Primary outcomes studies were clinical pregnancy rate, live birth rate and the ongoing pregnancy rate in COS-IUI cycles.Results: The clinical pregnancy rate in the recombinant hCG trigger group was 22.1% versus 17.78% in women with urinary hCG trigger, which was not statistically significant (0.96). Similarly the live birth rate was higher in rhCG (17.89%) group than the uhCG (13.33%) group of patients undergoing COD-IUI cycles.Conclusion: The findings in our study confirm that rhCG is similar in efficacy to uhCG in achieving positive pregnancy outcome during COH-IUI cycles. Therefore, it is more or less the cost factor and doctors preference that decides the type of ovulation trigger to be used.