Abstract

Aim: The present study aims to understand the association between first trimester serum vitamin B12 levels with serum homocysteine levels in pregnancy. Methodology: The study was conducted in the department of Obstetrics and Gynecology in association with department of Biochemistry, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital. A total of hundred pregnant women were recruited at their booking visit in the present study and subjected to serum folate, vitamin B12 and homocysteine level estimations. Results: More than 50% of women were found to be vitamin B12 deficient in the first trimester. Women practicing vegetarianism were found to have significantly high vitamin B12 deficiency (69.7%) as compared to non vegetarians (46.3%). Women with vitamin B12 deficiency in first trimester were found to be significantly hyperhomocysteinemic (44.44%) as compared to women with normal vitamin B12 levels (17.39%). Conclusion: There is a significant association of vitamin B12 deficiency in first trimester with hyperhomocysteinemia.