Abstract

Background: Preeclampsia (PE), a multisystem disorder specific to pregnancy is associatedwith considerable maternal and perinatal morbidity and mortality. Earlier, predictive tests were done late in second trimester with no scope for prevention. Prediction of PE in the late first trimester is made possible with an intense research focus on angiogenic markers and Doppler indices over recent years.  Objective: To predict preeclampsia using demographic factors, placental growth factor (PlGF) and uterine artery pulsatility index (PI) in combination in early pregnancy. Materials and methods: This was a prospective observational study done on 88 pregnant women attending the OPD between 11 and 14 weeks of gestation. Women who fulfilled the inclusion and exclusion criteria were enrolled in the study after obtaining informed consent. A detailed history was elicited and a thorough clinical examination was done after which, uterine artery Doppler was performed and the PI was calculated. 5 mL of venous blood were collected and PlGF levels estimated. All subjects were followed up till delivery and discharge. Development of preeclampsia, if any was identified. Results: Demographic factors, uterine artery PI and PlGF in combination for prediction of PE had sensitivity of 85.71% and negative predictive value (NPV) of 98.67% with p value 0.070. Conclusion: It is important to identify preeclampsia in pregnancy women because, by predicting the disease early it can be prophylactically treated with low dose aspirin thereby we can reduce perinatal and maternal morbidity and mortality. With the available literature and research articles, we have observed a better prediction rate for preeclampsia with a combined screening method using angiogenic markers, maternal characteristics and Doppler parameters.