Abstract

Objective: The objective of this study was to evaluate the clinicopathological pattern and survival outcome of Malignant Ovarian Germ Cell Tumors (MOGCTs). Materials and methods: Thirty seven patients with MOGCTs were retrospectively identified through hospital information system from 2013 to 2018. Tumors were staged according to the International Federation of Gynecology and Obstetrics staging system and histology was based on the WHO classification. Clinicopathological characteristics and overall survival and progression free survival were determined by the Kaplan–Meier method. All patients were included in the study. Results: The mean age of the patients was 19.9 ± 5.42 years. Most of them were unmarried (n = 31, 83.78%). The most common mode of presentation was pain abdomen and abdominal mass in 15 (40.54%) cases followed by abdominal pain alone in 12 (32.43%) cases, abdominal mass in four (10.81%) cases and incidental findings were in six (16.21%) cases. The most common histological type was immature teratoma in 14 (37.83%) followed by dysgerminoma in eight (21.62%), yolk sac tumor in seven (18.91%) and mixed germ cell tumor in seven (18.91%). Twenty seven (72.97%) patients presented in early stage of disease. The median follow up period was 36.75 (6-77) months. Progression free survival was 34.02 months and overall survival was 36.75 months and the overall survival rate was 94.59%. Five patients had disease relapse, two distant and three local recurrences. Conclusion: MOGCTs are rare. They generally affect the young women and are diagnosed at an early stage. They have excellent prognosis with fertility sparing surgery and adjuvant chemotherapy even in advanced stage.